X39 SCIENCE - CLINICAL TRIALS - PATENT
THE SCIENCE
The Science as to why X39 Patches are helping people is very simple:
1. GHK-Cu (Copper Peptide), which declines with age, has many health promoting effects on many tissues including activation of dormant Stem Cells.
2. X39 Phototherapy Devices increase GHK-Cu concentrations in the blood of people who wear them.
DOCUMENTED REGENERATIVE AND HEALING PROPERTIES OF GHK-Cu
Dr Loren Pickart, the scientist who discovered GHK-Cu (glycyl-L-histidyl-L-lysine-copper) in 1973, has extensively documented its regenerative and healing properties. His research provides profound insights into the peptide’s biological functions, supported by decades of scientific studies.
Key Findings by Dr. Pickart and Collaborators
Gene Expression Modulation
GHK-Cu impacts over 4,000 human genes, promoting beneficial changes in gene expression. It upregulates genes associated with tissue regeneration, DNA repair, and antioxidant defences while downregulating genes linked to inflammation and fibrosis. These effects underline its ability to "reset" tissue biology to a healthier state, as demonstrated in studies using genomic profiling tools such as the Broad Institute’s Connectivity Map and GenePattern software.
Collagen and Elastin Synthesis
GHK-Cu significantly enhances the production of collagen, elastin, and glycosaminoglycans, which are crucial for maintaining skin elasticity and firmness. Human and animal studies confirm its role in improving skin health, wound healing, and reducing visible signs of aging.
Wound Healing and Regeneration
Studies confirm that GHK-Cu accelerates wound healing by stimulating fibroblast activity, reducing oxidative damage, and promoting the formation of new blood vessels and nerve growth. It has shown efficacy in healing diabetic ulcers, ischemic wounds, and other chronic skin conditions.
Stem Cell Activation in Regeneration
Dr. Pickart’s research highlights GHK-Cu’s ability to activate dormant stem cells, potentially reverting differentiated cells to a more pluripotent state. This enables cells to participate in organ and tissue regeneration by enhancing mobility and facilitating repair processes. Studies demonstrate that GHK-Cu upregulates genes like p53 and RAD50, vital for DNA repair and cellular rejuvenation, further supporting its role in tissue healing and regeneration.
Anti-Inflammatory and Anti-Cancer Properties
GHK-Cu reduces chronic inflammation, a contributing factor to many diseases, including cancer. It decreases levels of inflammatory cytokines like TNF-α and interleukin-6. Additionally, its anti-cancer potential is linked to its ability to regulate tumour suppressor genes such as p53 and PTEN.
GHK-Cu Declines with Age
GHK (glycyl-L-histidyl-L-lysine) is a naturally occurring peptide found in human serum with levels averaging 200 ng/ml at age 20 but declining to an average of 80 ng/ml by age 60. People aged 20 have 2.5 times as much GHK as people aged 60.
Safety Profile
GHK-Cu is considered highly safe, with studies indicating minimal toxicity and adverse effects, even in long-term applications. This makes it an attractive candidate for therapeutic use in regenerative medicine and cosmetics.
Additional Insights on Stem Cell Function
Dr. Pickart’s studies emphasize GHK-Cu’s effects on genes relevant to stem cell activity. Research utilizing gene profiling identified significant changes in the expression of genes associated with cell cycle regulation and tissue regeneration. For instance:
The peptide’s broad-spectrum effects make it valuable in:
REFERENCES
1. Skin Regenerative and Anti-Cancer Actions of Copper Peptides
Loren Pickart and Anna Margolina
Published: 21 April 2018
https://www.mdpi.com/2079-9284/5/2/29
2. Regenerative and Protective Actions of the GHK-Cu Peptide in the Light of the New Gene Data
Loren Pickart and Anna Margolina
Published: 7 July 2018
https://www.mdpi.com/1422-0067/19/7/1987
3. The Effect of the Human Plasma Molecule GHK-Cu on Stem Cell Actions and Expression of Relevant Genes
Loren Pickart and Anna Margolina
Published: August 16, 2018
ResearchGate
4. The Effect of the Human Peptide GHK on Gene Expression Relevant to Nervous System Function and Cognitive Decline
Loren Pickart, Jessica Michelle Vasquez-Soltero and Anna Margolina
Published: 15 February 2017
Brain Sciences
CONCLUSION - As stated in this paper.
There are three sources of evidence on GHK actions:
5. The Potential of GHK as an Anti-aging Peptide
Yan Dou et al.
Published: March 27, 2020
https://pmc.ncbi.nlm.nih.gov/articles/PMC8789089/
Dr Loren Pickart, the scientist who discovered GHK-Cu (glycyl-L-histidyl-L-lysine-copper) in 1973, has extensively documented its regenerative and healing properties. His research provides profound insights into the peptide’s biological functions, supported by decades of scientific studies.
Key Findings by Dr. Pickart and Collaborators
Gene Expression Modulation
GHK-Cu impacts over 4,000 human genes, promoting beneficial changes in gene expression. It upregulates genes associated with tissue regeneration, DNA repair, and antioxidant defences while downregulating genes linked to inflammation and fibrosis. These effects underline its ability to "reset" tissue biology to a healthier state, as demonstrated in studies using genomic profiling tools such as the Broad Institute’s Connectivity Map and GenePattern software.
Collagen and Elastin Synthesis
GHK-Cu significantly enhances the production of collagen, elastin, and glycosaminoglycans, which are crucial for maintaining skin elasticity and firmness. Human and animal studies confirm its role in improving skin health, wound healing, and reducing visible signs of aging.
Wound Healing and Regeneration
Studies confirm that GHK-Cu accelerates wound healing by stimulating fibroblast activity, reducing oxidative damage, and promoting the formation of new blood vessels and nerve growth. It has shown efficacy in healing diabetic ulcers, ischemic wounds, and other chronic skin conditions.
Stem Cell Activation in Regeneration
Dr. Pickart’s research highlights GHK-Cu’s ability to activate dormant stem cells, potentially reverting differentiated cells to a more pluripotent state. This enables cells to participate in organ and tissue regeneration by enhancing mobility and facilitating repair processes. Studies demonstrate that GHK-Cu upregulates genes like p53 and RAD50, vital for DNA repair and cellular rejuvenation, further supporting its role in tissue healing and regeneration.
Anti-Inflammatory and Anti-Cancer Properties
GHK-Cu reduces chronic inflammation, a contributing factor to many diseases, including cancer. It decreases levels of inflammatory cytokines like TNF-α and interleukin-6. Additionally, its anti-cancer potential is linked to its ability to regulate tumour suppressor genes such as p53 and PTEN.
GHK-Cu Declines with Age
GHK (glycyl-L-histidyl-L-lysine) is a naturally occurring peptide found in human serum with levels averaging 200 ng/ml at age 20 but declining to an average of 80 ng/ml by age 60. People aged 20 have 2.5 times as much GHK as people aged 60.
Safety Profile
GHK-Cu is considered highly safe, with studies indicating minimal toxicity and adverse effects, even in long-term applications. This makes it an attractive candidate for therapeutic use in regenerative medicine and cosmetics.
Additional Insights on Stem Cell Function
Dr. Pickart’s studies emphasize GHK-Cu’s effects on genes relevant to stem cell activity. Research utilizing gene profiling identified significant changes in the expression of genes associated with cell cycle regulation and tissue regeneration. For instance:
- Upregulated Genes: These include RAD50 (DNA repair) and p53 (a key regulator of cell cycle and tumour suppression).
- Stem Cell Activation: GHK-Cu promotes reactivation of dormant stem cells, improving their functionality in repairing damaged tissues and reversing age-related gene expression changes.
The peptide’s broad-spectrum effects make it valuable in:
- Anti-aging skincare products
- Wound healing treatments
- Therapies for chronic inflammatory conditions
- Potential cancer prevention strategies
REFERENCES
1. Skin Regenerative and Anti-Cancer Actions of Copper Peptides
Loren Pickart and Anna Margolina
Published: 21 April 2018
https://www.mdpi.com/2079-9284/5/2/29
2. Regenerative and Protective Actions of the GHK-Cu Peptide in the Light of the New Gene Data
Loren Pickart and Anna Margolina
Published: 7 July 2018
https://www.mdpi.com/1422-0067/19/7/1987
3. The Effect of the Human Plasma Molecule GHK-Cu on Stem Cell Actions and Expression of Relevant Genes
Loren Pickart and Anna Margolina
Published: August 16, 2018
ResearchGate
4. The Effect of the Human Peptide GHK on Gene Expression Relevant to Nervous System Function and Cognitive Decline
Loren Pickart, Jessica Michelle Vasquez-Soltero and Anna Margolina
Published: 15 February 2017
Brain Sciences
CONCLUSION - As stated in this paper.
There are three sources of evidence on GHK actions:
- The best data is in vivo mammalian data, including human clinical studies. As reviewed in this paper, these studies give overwhelming evidence of GHK’s effects on cells and tissue growth, as well as anti-cancer, anti-oxidant, wound-healing, anti-inflammation, anti-pain, anti-anxiety and skin regeneration actions.
- A second form of data is in vitro cell culture and organ culture results. Culture results give evidence about the effect of GHK on cellular production of collagen and other structural proteins, the effect on stem cell function, the recovery of cellular function after anticancer radiation or ultraviolet radiation, and sensitivity of cells to oxidative molecules.
- A third source of data is in Human Gene expression. Data analysis found that GHK induces a 50% or greater (plus or minus) change of expression in 31.2% of human genes, affecting genes linked to multiple biochemical pathways in many organs and tissue, including the nervous system.
5. The Potential of GHK as an Anti-aging Peptide
Yan Dou et al.
Published: March 27, 2020
https://pmc.ncbi.nlm.nih.gov/articles/PMC8789089/
6. Boston Children’s Hospital – Stem Cell Program
Scientists are discovering that many tissues and organs contain a small number of adult stem cells that help maintain them. Adult stem cells have been found in the brain, bone marrow, lung, blood vessels, skeletal muscle, skin, teeth, gut, liver, and other (although not all) organs and tissues. They are thought to live in a specific area of each tissue, where they may remain dormant (sometimes for years), dividing and creating new cells only when they are activated by tissue injury, disease or anything else that makes the body need more cells.
Boston Children’s Hospital Link
Boston Children’s Hospital Link
MIRACULOUS CHANGES IN PEOPLE WEARING X39
Nearly all of the changes observed by people and shared in the TESTIMONIALS can be attributed to the 'Body Healing Itself' as a result of the Regenerative and Protective Actions that have been attributed to GHK-Cu in the published research papers referenced and listed above.
Nearly all of the changes observed by people and shared in the TESTIMONIALS can be attributed to the 'Body Healing Itself' as a result of the Regenerative and Protective Actions that have been attributed to GHK-Cu in the published research papers referenced and listed above.
X39 PHOTOTHERAPY DEVICE - CLINICAL TRIALS
1. Double-Blind Testing of the LifeWave X39 Patch to Determine GHK-Cu Production Levels
A double-blind test published in the journal Internal Medicine Research showed a significant increase in copper-peptide concentrations in the blood of subjects who had worn patches X39 patches for 1 week.
https://cdn.sanity.io/files/abq8rp7f/production/8a5cac96f857e8b0c9ded076518f40d03ab8c688.pdf
https://cdn.sanity.io/files/abq8rp7f/production/8a5cac96f857e8b0c9ded076518f40d03ab8c688.pdf
2. Phototherapy Induced Metabolism Change Produced by the LifeWave X39 Non-transdermal Patch
A double-blind randomized control study published in the International Journal of Research Studies in Medical and Health Sciences revealed that X39 patches caused a significant increase in the production of 8 amino acids, which improved short-term memory, sleep, and vitality.
https://cdn.sanity.io/files/abq8rp7f/production/04b42a41b6b6591004dab59a184ee71862af161a.pdf
https://cdn.sanity.io/files/abq8rp7f/production/04b42a41b6b6591004dab59a184ee71862af161a.pdf
3. Changes in Tripeptides Produced by the LifeWave X39 Patch
This pilot study explored changes in amounts of GHK and GHK-Cu present in blood due to wearing the LifeWave X39 patch for 1 week. There was a significant increase of GHK in blood seen at 24 hours and again at 7 days.
https://cdn.sanity.io/files/abq8rp7f/production/ad38f8d2c09718acd1515f7527bf9a2084c59c0f.pdf
https://cdn.sanity.io/files/abq8rp7f/production/ad38f8d2c09718acd1515f7527bf9a2084c59c0f.pdf
4. Experimental Study of LifeWave, Inc. X39 Patches
This pilot study demonstrates a statistically significant positive change in the biofields of members in the experimental group when compared to the control group.
https://cdn.sanity.io/files/abq8rp7f/production/a6c7b37f3d754fdf636feb5c1664ffe86eb2bba8.pdf
https://cdn.sanity.io/files/abq8rp7f/production/a6c7b37f3d754fdf636feb5c1664ffe86eb2bba8.pdf
5. LifeWave X39 Pilot Demonstrates Light Triggered Changes
The purpose of this study was to determine if metabolic and physiological changes were produced by participants wearing the LifeWave non-transdermal X39 phototherapy patch. While this is a small sample of convenience, the positive results in this study suggest that further investigation needs to be done. Both the effect that appears to produce a number of significant amino acid changes in a short period of time and the improvement in short-term memory, which are particularly relevant to an ageing population, should be explored.
https://cdn.sanity.io/files/abq8rp7f/production/97728bd5c9f43fd54a5a30c029cb2fc4c03c8dd3.pdf
https://cdn.sanity.io/files/abq8rp7f/production/97728bd5c9f43fd54a5a30c029cb2fc4c03c8dd3.pdf
6. Non-Invasive Scanning and Effect of LifeWave X39TM Patches on Brain as Seen with P3 Brain Mapping: Preliminary Results
All participants showed dramatic changes in their scalp topographic maps reporting the amplitude of the P300 recording for each channel and also in their coherence maps
https://cdn.sanity.io/files/abq8rp7f/production/73b1cafb1839d1905a6d1fe76623358c2eb1ac9f.pdf
https://cdn.sanity.io/files/abq8rp7f/production/73b1cafb1839d1905a6d1fe76623358c2eb1ac9f.pdf
7. Metabolic Implications of the LifeWave X39 Patch - Study 1
This study, as designed, is fairly comprehensive in nature, exploring the metabolic and physiologic aspects of the LifeWave X39 patch. In addition the questionnaires which were administered cover a range of previously reported experiences with the X39 patches. These include quality of sleep improvement, memory improvement, feelings of vitality, reduction of pain and inflammation, and an overall sense of well-being. This study provides a short term picture of the lived experience of participants who are wearing the LifeWave X39 Phase III patch daily.
https://cdn.sanity.io/files/abq8rp7f/production/a443b5485b87d6c8c249bc0208a6f813393f8824.pdf
https://cdn.sanity.io/files/abq8rp7f/production/a443b5485b87d6c8c249bc0208a6f813393f8824.pdf
8. Metabolic Implications of the LifeWave X39 Patch - Study 4
The data show improvement in blood pressure, 17 statistically significant amino acid changes over the 7 days, significant improvement in anti-inflammatory response, improvement in sleep levels, reduction in blood pressure, improvement in short-term memory, improvement in reported feelings of vitality and consistency in reporting across the study suggest that further research with a larger sample size be done.
Since this study was done on an aging population, it is also important to note that the patch appears to support the movement back toward fitness of the gut system and improved adaptability to change.
https://cdn.sanity.io/files/abq8rp7f/production/85e330b2b2280d1e7c802889be84830620e1e284.pdf
Since this study was done on an aging population, it is also important to note that the patch appears to support the movement back toward fitness of the gut system and improved adaptability to change.
https://cdn.sanity.io/files/abq8rp7f/production/85e330b2b2280d1e7c802889be84830620e1e284.pdf
9. Changes in GHK and GHK-Cu in blood produced by the LifeWave X39 Patch
This study explored the changes in amounts of GHK and GHK-CU present in the blood as a result of wearing the LifeWave X39 patch for 1 week. There was a significant increase in GHK in the blood which was seen at 24 hours and at 7 days.
https://cdn.sanity.io/files/abq8rp7f/production/f84102174ebc88fba113a54dc4319ac074b6ab19.pdf
https://cdn.sanity.io/files/abq8rp7f/production/f84102174ebc88fba113a54dc4319ac074b6ab19.pdf
X39 - PATENTED JULY 21st, 2020
To Download the Patent click on 'Download File' below:
| X39 Patent |
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